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The exact meaning of the number has been a topic of hot debate. It is commonly considered to denote Emperor Nero, who was cruel to Christians.
Symbolically, the number 7 has been thought to represent completeness. Hence, this number (in question) in contract signifies incompleteness and imperfection. Or alternatively, a quality of being complete in sinfulness.
Which number am I talking about?

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666 or the number of the Beast
This is in contrast to the Angelic 777.

Revelation 13:18 says, “Here is wisdom. Let him who has understanding calculate the number of the beast, for the number is that of a man; and his number is 666.”. Hence marking any person with this number to be devil incarnate.
Read More about the (deep) Interpretation of the number.